139.
Local recurrence rate after surgical excision of highly differentiated
liposarcomas
Sune Frederik Jauffred, Maj Kornø, Michael Mørk Petersen
Tumorsektionen, Ortopædkirurgisk klinik Rigshospitalet; Urologisk klinik,
Rigshospitalet; Tumorsektionen, Ortopædkirurgisk klinik, Rigshospitalet
Background:
Highly differentiated liposarcomas (HDL) is a rare low-
malignant tumour that predominantly arises in the extremities, retroperitoneum
or thorax. These tumours have a relatively high rate of local recurrence after
surgical resection and can in rare cases dedifferentiate into a high-malignant
sarcoma.
Purpose / Aim of Study:
The purpose of this study was to determine the local
recurrence rate among surgically excised HDL and to determine the rate of
dedifferentiation.
Materials and Methods:
We retrospectively assessed all HDL surgically
excised at our clinic between 1997 and 2006; 35 patients (F/M=17/18, mean
age 59 (34-85) years). Patients with local recurrence of previously (before the
start of the inclusion period) excised lipomatous tumours, were excluded. The
length of local recurrence-free time, and appearance of local recurrence,
metastases or histological dedifferentiation was estimated from the patient
files, and beyond the last follow-up in our clinic assessed from the National
Pathology Registry (NPP). Survival data were extracted from the Danish
Centralised Civil Registry.
Findings / Results:
The surgical margins obtained at the initial surgery were
intralesional (n=5), marginal (n=22), wide (n=3) or inconclusive (n=5). The
median clinical follow-up for patients without recurrences was 49 (5-126)
months, and they were recurrence free in 116 (69-167) months according to
NPP. 6 had local recurrence 41 (6-73) months after the initial tumour resection
and the histological examination showed that three tumours had
dedifferentiated. We did not record any cases of distant metastasis. 11 patients
have died during the follow-up period.
Conclusions:
Despite (intended) marginal or intralesional surgery in most
cases the treatment strategy seemed reasonable with relatively few local
recurrences, few dedifferentiated tumours and no metastases.
